R&D Systems Inc. Tocris Bioscience Boston Biochem

(-)-Bicuculline methiodide

Cat. No. 2503

(-)-Bicuculline methiodide C21H20INO6 [40709-69-1]

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Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide

Biological Activity

Methiodide form of classical GABAA receptor antagonist (+)-bicuculline (Cat. No. 0130). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

Technical Data

M.Wt:
509.3
Formula:
C21H20INO6
Solubility:
Soluble to 20 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
40709-69-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. PMID: 1247886.

Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268. PMID: 10390643.

Chan et al (2006) Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 55 1080. PMID: 16567532.

Kurt et al (2006) Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex. Hear.Res. 212 224. PMID: 16442250.

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Keywords: (-)-Bicuculline methiodide, supplier, Water-soluble, GABAA, antagonists, Receptors

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