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[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat)

Cat. No. 1176

[Leu31,Pro34]-Neuropeptide Y (human) Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

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Alternative Name: [Leu³¹,Pro³⁴]-NPY (human)

Biological Activity

High affinity neuropeptide Y Y₁ receptor agonist (K_i = 0.39 nM). Also shows affinity for Y₄ and Y₅ receptors.

Technical Data

M.Wt:

4241

Formula:

C₁₈₉H₂₈₄N₅₄O₅₆S

Sequence:

YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY

(Modifications: Tyr-36 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

132699-73-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Fuhlendorff et al (1990) [Leu³¹, Pro³⁴]Neuropeptide Y: a specific Y₁ receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182. PMID: 2153286.

Bard et al (1995) Cloning and functional expression of a human Y₄ subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762. PMID: 7592911.

Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y₁-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507. PMID: 9723965.

Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143. PMID: 9549761.

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Keywords: [Leu31,Pro34]-Neuropeptide Y (human), supplier, NPY, Y1, receptor, agonists, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (human), neuropeptides

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