KT 5720

Cat. No. 1288

KT 5720 C32H31N3O5 [108068-98-0]

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Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester

Biological Activity

Potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.

Technical Data

M.Wt:
537.61
Formula:
C32H31N3O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
108068-98-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Kase et al (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem.Biophys.Res.Commun. 142 436. PMID: 3028414.

Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626. PMID: 1528872.

Cabell et al (1993) Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. Int.J.Dev. Neurosci. 11 357. PMID: 7689287.

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Keywords: KT 5720, supplier, Selective, protein, kinases, A, inhibitors, PKA, cAMP, KT5720, Tocris Bioscience, Protein Kinase A Inhibitors

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