AM 92016 hydrochloride
Cat. No. 0876
Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(
Biological ActivityA specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Conners et al (1992) Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958. PMID: 1393293.
Hagerty et al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417. PMID: 8794994.
Lei and Brown (1998) Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260. PMID: 9550297.
Palen et al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268. PMID: 15967421.
If you know of a relevant citation for this product please let us know.
Keywords: AM 92016 hydrochloride, supplier, KV, channel, blocker, Potassium, Channels, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, voltage-gated, voltage-dependent, K+, AM92016, hydrochloride
Find multiple products by catalog number
New Products in this Area
Potent and selective TASK-1 channel blockerHMR 1556
Potent and selective Iks channel blockerNS 19504
Activator of BKCa (KCa1.1) channelsTRAM 39
Potent KCa3.1 blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.