AM 92016 hydrochloride
Cat. No. 0876
Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(
Biological ActivityA specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Conners et al (1992) Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958. PMID: 1393293.
Hagerty et al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417. PMID: 8794994.
Lei and Brown (1998) Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260. PMID: 9550297.
Palen et al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268. PMID: 15967421.
If you know of a relevant citation for this product please let us know.
Keywords: AM 92016 hydrochloride, supplier, KV, channel, blocker, Potassium, Channels, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, voltage-gated, voltage-dependent, K+, AM92016, hydrochloride
Find multiple products by catalog number
New Products in this Area
Potent KCa3.1 blockerBDS I
Potent and reversible Kv3.4 potassium channel blocker; neuroprotectiveAgitoxin 2
Potent Shaker K+ channel blockerMaxiPost
Potassium channel modulator; exerts subtype-specific effectsML 277
Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current
August 22 - 24, 2014