R&D Systems Inc. Tocris Bioscience Boston Biochem

AM 92016 hydrochloride

Cat. No. 0876

AM 92016 hydrochloride C19H24Cl2N2O4S.HCl [133229-11-5]

Price and Availability

For AM 92016 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride

Biological Activity

A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.

Technical Data

M.Wt:
483.84
Formula:
C19H24Cl2N2O4S.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
133229-11-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Conners et al (1992) Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958. PMID: 1393293.

Hagerty et al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417. PMID: 8794994.

Lei and Brown (1998) Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260. PMID: 9550297.

Palen et al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268. PMID: 15967421.

If you know of a relevant citation for this product please let us know.

Keywords: AM 92016 hydrochloride, supplier, KV, channel, blocker, Potassium, Channels, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, voltage-gated, voltage-dependent, K+, AM92016, hydrochloride

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Poster

A summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

ML 297

Selective Kir3.1/3.2 (GIRK1/2) channel activator

ML 365

Potent and selective TASK-1 channel blocker

HMR 1556

Potent and selective Iks channel blocker

NS 19504

Activator of BKCa (KCa1.1) channels

Sign-up for new product e-alerts
divider line

Bio-Techne Events

12th Congress of the French Neuroscience Society

12th Congress of the French Neuroscience Society

May 19 - 22, 2015

Montpelier, France