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AM 92016 hydrochloride

Cat. No. 0876

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Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride

Biological Activity

A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.

Technical Data

M.Wt:

483.84

Formula:

C₁₉H₂₄Cl₂N₂O₄S.HCl

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Store at RT

CAS No:

178894-81-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Conners et al (1992) Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958. PMID: 1393293.

Hagerty et al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417. PMID: 8794994.

Lei and Brown (1998) Inhibition by compound II, a sotalol analogue, of delayed rectifier current (i_K) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260. PMID: 9550297.

Palen et al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268. PMID: 15967421.

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