Cat. No. 0590
Chemical Name: [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Biological ActivityAntagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Aulakh et al (1992) Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J.Pharmacol.Exp.Ther. 263 588. PMID: 1432690.
Bagdy et al (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur.J.Pharmacol. 210 285. PMID: 1535317.
Miller et al (1992) Agonist activity of sumatriptan and metergoline at the human 5-HT1Dβ receptor in the action of sumatriptan. Eur.J.Pharmacol. 227 99. PMID: 1330643.
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Keywords: Metergoline phenylmethyl ester, supplier, moderate, affinity, 5-HT6, high, 5-HT7, 5-HT1, 5-HT2, antagonists, 5-HT1D, ligand, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, Non-Selective
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