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HC 030031

Cat. No. 2896

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Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

Biological Activity

Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC₅₀ values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or Na_V1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.

Technical Data

M.Wt:

355.39

Formula:

C₁₈H₂₁N₅O₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

349085-38-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

McNamara et al (2007) TRPA1 mediates formalin-induced pain. Proc.Natl.Acad.Sci.USA 104 13525.

Taylor-Clark et al (2008) Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1. Mol.Pharmacol. 73 274. PMID: 18000030.

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