HC 030031

Cat. No. 2896

HC 030031 C18H21N5O3 [349085-38-7]

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Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

Biological Activity

Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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McNamara et al (2007) TRPA1 mediates formalin-induced pain. Proc.Natl.Acad.Sci.USA 104 13525.

Taylor-Clark et al (2008) Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1. Mol.Pharmacol. 73 274. PMID: 18000030.

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Keywords: HC 030031, supplier, Selective, TRPA1, blockers, Channels, Transient, Receptor, Potential, HC030031

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