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SR 11302

Cat. No. 2476

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Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid

Biological Activity

Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC₅₀ > 1 μM for RARα, RARβ, RARγ and RXRα).

Technical Data

M.Wt:

376.54

Formula:

C₂₆H₃₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

160162-42-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Huang et al (1997) Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 94 5826.

Shiohara et al (1999) Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93 2057. PMID: 10068679.

Fanjul et al (2002) A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372 107.

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