R&D Systems Inc. Tocris Bioscience Boston Biochem

Resveratrol

Cat. No. 1418

Resveratrol C14H12O3 [501-36-0]

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Chemical Name: 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol

Biological Activity

A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1.

Technical Data

M.Wt:
228.25
Formula:
C14H12O3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
501-36-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Kimura et al (1985) Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim.Biophys.Acta 834 275. PMID: 3922423.

Chun et al (1999) Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem.Biophys.Res.Commun. 262 20. PMID: 10448061.

Bowers et al (2000) Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinology 141 3657. PMID: 11014220.

Fremont (2000) Biological effects of resveratrol. Life Sci. 66 663. PMID: 10680575.

Baur and Sinclair (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat.Rev.Drug Discov. 5 493. PMID: 16732220.

Baptista et al (2013) Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer. Oncotarget 4 1673. PMID: 24127549.

If you know of a relevant citation for this product please let us know.

Keywords: Resveratrol, supplier, Antitumor, anti-oxidant, agent, Cyclooxygenase, inhibitor, COX, Oxygenases, Oxidases

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