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L-689,560

Cat. No. 0742

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Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline

Biological Activity

Very potent antagonist at the glycine-NMDA site. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M.Wt:

380.23

Formula:

C₁₇H₁₅Cl₂N₃O₃

Solubility:

Soluble to 25 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

139051-78-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Leeson et al (1991) trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists. Med.Chem.Res. 1 64.

Leeson et al (1992) 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor. J.Med.Chem. 35 1954. PMID: 1534584.

Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149. PMID: 10740291.

If you know of a relevant citation for this product please let us know.

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Keywords: L-689,560, supplier, potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, L689560, merck

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