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CH 275

Cat. No. 2454

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Biological Activity

Potent somatostatin receptor 1 (sst₁) agonist; displays selectivity for sst₁ (IC₅₀ values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst₁, sst₃, sst₄, sst₂ and sst₅ respectively). Attenuates somatostatin release in the rat nucleus accumbens.

Licensing Information

Sold with the permission of the SALK Institute.

Technical Data

M.Wt:

1485.8

Formula:

C₇₄H₉₆N₁₄O₁₅S₂

Sequence:

CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)

Solubility:

Soluble to 0.30 mg/ml in water

Storage:

Store at -20°C

CAS No:

174688-78-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689. PMID: 10329447.

Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238. PMID: 11405660.

Vasilaki et al (2004) The somatostatin receptor (sst₁) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612. PMID: 15380378.

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