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NF 157

Cat. No. 2450

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Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Biological Activity

Purinergic receptor antagonist that potently inhibits P2Y₁₁ receptor activity (IC₅₀ = 463 nM). Displays selectivity for P2Y₁₁ and P2X₁ receptors over P2Y₁, P2Y₂ , P2X₂, P2X₃, P2X₄ and P2X₇ receptors. Inhibits NAD⁺-induced activation of human granulocytes.

Technical Data

M.Wt:

1437.08

Formula:

C₄₉H₂₈F₂N₆Na₆O₂₃S₆

Solubility:

Soluble to 50 mM in water

Storage:

Desiccate at RT

CAS No:

104869-26-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ullmann et al (2005) Synthesis and structure-activity relationships of suramin-derived P2Y₁₁ receptor antagonists with nanomolar potency. J.Med.Chem. 48 7040. PMID: 16250663.

Moreschi et al (2006) Extracellular NAD⁺ is an agonist of the human P2Y₁₁ purinergic receptor in human granulocytes. J.Biol.Chem. 281 31419. PMID: 16926152.

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