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2-Iodomelatonin

Cat. No. 0737

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Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide

Biological Activity

Potent melatonin agonist (pK_i values are 10.55 and 9.87 at human recombinant MT₁ and MT₂ receptors respectively). 2-[¹²⁵I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Technical Data

M.Wt:

358.18

Formula:

C₁₃H₁₅IN₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

93515-00-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Dubocovich and Takahashi (1987) Use of 2-[¹²⁵l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 84 3916. PMID: 3035559.

Suiciak et al (1991) Quantitative pharmacological analysis of 2-[¹²⁵l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 11 2855. PMID: 1652626.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

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Keywords: 2-Iodomelatonin, supplier, High, affinity, melatonin, agonists, MT, Receptors

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