Cat. No. 2411
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide
Biological ActivityPotent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
(Modifications: Trp-1 = Boc-Trp, Lys-3 = Lys(Tac), Phe-5 = N-methyl-Phe & C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951.
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346.
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699. PMID: 1513850.
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Keywords: A-71623, supplier, Potent, selective, CCK1, agonists, Suppresses, feeding, Cholecystokinin1, Receptors, A71623
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December 16, 2013