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RJR 2429 dihydrochloride

Cat No. 1271

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Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride

Biological Activity

Potent nAChR agonist that displays selectivity for α4β2 (K_i = 1 nM) and α1βγδ subtypes (EC₅₀ values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC₅₀ = 2 nM) and inhibits ion flux in thalamic neurons (IC₅₀ = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.

Technical Data

M.Wt:

261.19

Formula:

C₁₂H₁₆N₂.2HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[91556-75-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

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References

Bencherif et al (1998) The heterocyclic substituted pyridine derivative (±)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 284 886. Yokotani et al (2002) Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland. Eur.J.Pharmacol. 446 83. Bhatti et al (2008) Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J.Org.Chem. 73 3497.

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