Ro 90-7501

Cat. No. 2408

Ro 90-7501 C20H16N6 [293762-45-5]

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Chemical Name: 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine

Biological Activity

Inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).

Technical Data

M.Wt:
340.39
Formula:
C20H16N6
Solubility:
Soluble to 10 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
293762-45-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bohrmann et al (2000) Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 130 232. PMID: 10940228.

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View Related Products by Target

Keywords: Ro 90-7501, supplier, inhibitors, Aβ4, β42, beta42, fibril, formation, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, beta, Peptides, Ro90-7501, amyloidbeta, amyloidb, amyloidβ

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