R&D Systems Inc. Tocris Bioscience Boston Biochem

Acarbose

Cat. No. 2673

Acarbose C25H43NO18 [56180-94-0]

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Alternative Name: Bay-g 5421

Chemical Name: O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose

Biological Activity

Inhibitor of intestinal α-glucosidase (IC50 = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.

Technical Data

M.Wt:
645.25
Formula:
C25H43NO18
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at RT
CAS No:
56180-94-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Krause et al (1982) Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor acarbose (BAY g 5421). Digestion 23 232. PMID: 6754513.

Balfour and McTavish (1993) Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 46 1025. PMID: 7510610.

Oki et al (2000) Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol.Pharm.Bull. 23 1084. PMID: 10993209.

If you know of a relevant citation for this product please let us know.

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Keywords: Acarbose, supplier, Glucosidase, alpha, inhibitors, intestinal, Glycosylases, Carbohydrate, Metabolism, Bay-g5421

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