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Eplerenone

Cat. No. 2397

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Alternative Names: Inspra, Epoxymexrenone

Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester

Biological Activity

Selective mineralocorticoid (aldosterone) receptor antagonist (IC₅₀ = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC₅₀ > 10 μM). Orally active antihypertensive in vivo.

Technical Data

M.Wt:

414.5

Formula:

C₂₄H₃₀O₆

Solubility:

Soluble to 10 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

107724-20-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650. PMID: 2949071.

McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190. PMID: 11714095.

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