R&D Systems Inc. Tocris Bioscience Boston Biochem

Eplerenone

Cat. No. 2397

Eplerenone C24H30O6 [107724-20-9]

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Alternative Names: Inspra, Epoxymexrenone

Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester

Biological Activity

Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data

M.Wt:
414.5
Formula:
C24H30O6
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
107724-20-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650. PMID: 2949071.

McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190. PMID: 11714095.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Eplerenone, supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors

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