R&D Systems Inc. Tocris Bioscience Boston Biochem

1400W dihydrochloride

Cat. No. 1415

1400W dihydrochloride C10H15N3.2HCl [214358-33-5]

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Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride

Biological Activity

Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo.

Technical Data

M.Wt:
250.17
Formula:
C10H15N3.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
214358-33-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Garvey et al (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J.Biol.Chem. 272 4959. PMID: 9030556.

Thomsen et al (1997) Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 57 3300. PMID: 9242464.

Parmentier et al (1999) Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br.J.Pharmacol. 127 546. PMID: 10385257.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: 1400W dihydrochloride, supplier, Potent, selective, iNOS, inhibitor, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases

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