Cat. No. 1415
Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride
Biological ActivitySlow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Garvey et al (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J.Biol.Chem. 272 4959. PMID: 9030556.
Thomsen et al (1997) Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 57 3300. PMID: 9242464.
Parmentier et al (1999) Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br.J.Pharmacol. 127 546. PMID: 10385257.
If you know of a relevant citation for this product please let us know.
Keywords: 1400W dihydrochloride, supplier, Potent, selective, iNOS, inhibitor, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases
Find multiple products by catalog number
Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.