8-Hydroxy-DPAT hydrobromideCat No. 0529 |
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Alternative Name: 8-OH-DPAT hydrobromide Chemical Name: (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide |
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Biological Activity
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Other Information
Certificate of Analysis / MSDS
References
Middlemiss et al (1983) 8-OH-DPAT discriminates between subtypes of the 5HT1 recognition site. Eur.J.Pharmacol. 105 365. Helton and Colbert (1994) Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 46 902. Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1. Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865.
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Keywords: 8-Hydroxy-DPAT hydrobromide, moderate, affinity, 5-HT7, 5-HT1A, agonists, Selective, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT1
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