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Fasudil hydrochloride

Cat. No. 0541

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Alternative Name: HA 1077

Biological Activity

Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC₅₀ = 10.7 μM). Ca²⁺ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.

Technical Data

M.Wt:

327.83

Formula:

C₁₄H₁₇N₃O₂S.HCl

Solubility:

Soluble to 100 mM in water and to 75 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

103745-39-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Shirotani et al (1991) A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture. J.Pharmacol.Exp.Ther. 259 738. PMID: 1941621.

Arai et al (1993) Inhibition by the protein kinase inhibitor HA-1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. PMID: 8240400.

Satoh et al (1996) Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils. Br.J.Pharmacol. 118 1592. PMID: 8842419.

Sward et al (2000) Inhibition of Rho-associated kinase blocks agonist-induced Ca²⁺ sensitization of myosin phosphorylation and force in guinea-pig ileum. J.Physiol. 522 33. PMID: 10618150.

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Keywords: Fasudil hydrochloride, supplier, inhibitors, cyclic, nucleotide, dependent-, Rho-kinases, HA1077

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