R&D Systems Inc. Tocris Bioscience Boston Biochem

GR 46611

Cat. No. 0864

GR 46611
 C23H27N3O2 [185259-85-2]

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Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Biological Activity

5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
377.49
Formula:
C23H27N3O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Storage:
Store at RT
CAS No:
185259-85-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

References

Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253. PMID: 8057272.

Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: GR 46611, supplier, 5-HT1D, agonists, Serotonin, Receptors, GR46611, GlaxoSmithKline, GSK

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