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GR 46611Cat. No. 0864 |
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Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide |
Biological Activity
5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.Licensing Information
Sold with the permission of GlaxoSmithKlineTechnical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253. PMID: 8057272.
Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14.
If you know of a relevant citation for this product please let us know.
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Keywords: GR 46611, supplier, 5-HT1D, agonists, Serotonin, Receptors, GR46611, GlaxoSmithKline, GSK
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