GR 46611

Cat. No. 0864

GR 46611
 C23H27N3O2 [185259-85-2]

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Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Biological Activity

5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

Soluble to 50 mM in DMSO and to 10 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet


Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253. PMID: 8057272.

Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14.

If you know of a relevant citation for this product please let us know.

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Keywords: GR 46611, supplier, 5-HT1D, agonists, Serotonin, Receptors, GR46611, GlaxoSmithKline, GSK, 5-HT1D Receptor Agonists

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