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U 73122Cat. No. 1268 |
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Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione |
Biological Activity
Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC50 values of 1-5 μM. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 < 50 nM) and exhibits antinociceptive activity in vivo. Negative control U 73343 (Cat. No. 4133) also available.Licensing Information
Sold with the permission of PharmaciaTechnical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Resources
Other Information
Certificate of Analysis / Safety Data Sheet
References
Bleasdale et al (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J.Pharmacol.Exp.Ther. 255 756. PMID: 2147038.
Smith et al (1996) U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions. J.Pharmacol.Exp.Ther. 278 320. PMID: 8764366.
Shi et al (2008) Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc.Natl.Acad.Sci.U.S.A. 105 20004. PMID: 19066214.
If you know of a relevant citation for this product please let us know.
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Keywords: U 73122, supplier, Phospholipases, C, inhibitors, PC-PLC, PI-PLC, Esterases, U73122
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