R&D Systems Inc. Tocris Bioscience Boston Biochem

U 73122

Cat. No. 1268

U 73122 C29H40N2O3 [112648-68-7]

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Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

Biological Activity

Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC50 values of 1-5 μM. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 < 50 nM) and exhibits antinociceptive activity in vivo. Negative control U 73343 (Cat. No. 4133) also available.

Licensing Information

Sold with the permission of Pharmacia

Technical Data

M.Wt:
464.65
Formula:
C29H40N2O3
Solubility:
Soluble to 2 mM in ethanol and to 5 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
112648-68-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Bleasdale et al (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J.Pharmacol.Exp.Ther. 255 756. PMID: 2147038.

Smith et al (1996) U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions. J.Pharmacol.Exp.Ther. 278 320. PMID: 8764366.

Shi et al (2008) Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc.Natl.Acad.Sci.U.S.A. 105 20004. PMID: 19066214.

If you know of a relevant citation for this product please let us know.

Keywords: U 73122, supplier, Phospholipases, C, inhibitors, PC-PLC, PI-PLC, Esterases, U73122

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