Cat. No. 1268
Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10
Biological ActivityPhospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC50 values of 1-5 μM. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 < 50 nM) and exhibits antinociceptive activity in vivo. Negative control U 73343 (Cat. No. 4133) also available.
Licensing InformationSold with the permission of Pharmacia
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bleasdale et al (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J.Pharmacol.Exp.Ther. 255 756. PMID: 2147038.
Smith et al (1996) U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions. J.Pharmacol.Exp.Ther. 278 320. PMID: 8764366.
Shi et al (2008) Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc.Natl.Acad.Sci.U.S.A. 105 20004. PMID: 19066214.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: U 73122, supplier, Phospholipases, C, inhibitors, PC-PLC, PI-PLC, Esterases, U73122
Find multiple products by catalog number
New Products in this Area
Selective secreted phospholipase A2 (sPLA2) inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.