Home » Pharmacology » Ion Channels » Potassium Channels » Non-selective / Other Potassium Channels » DMP 543

DMP 543

Cat. No. 2330

Price and Availability

For DMP 543 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Biological Activity

K⁺ channel blocker and acetylcholine release stimulator. Potently enhances K⁺-stimulated [³H]-ACh release from rat hippocampal slices (EC₅₀ = 700 nM), and also increases release of dopamine and glutamate (EC₅₀ values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo.

Technical Data

M.Wt:

412.44

Formula:

C₂₆H₁₈F₂N₂O

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

160588-45-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615. PMID: 9804701.

Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724. PMID: 9580619.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Acetylcholine Muscarinic Receptors Acetylcholine Nicotinic Receptors Non-selective / Other Potassium Channels

Non-selective Muscarinics Other Acetylcholine Potassium Channels

Keywords: DMP 543, supplier, K+, channels, blockers, potent, ACh, release, enhancer, Potent, orally, active, Potassium, Channels, Non-Selective, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, DMP543