R&D Systems Inc. Tocris Bioscience Boston Biochem

DMP 543

Cat. No. 2330

DMP 543 C26H18F2N2O [160588-45-4]

Price and Availability

For DMP 543 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Biological Activity

K+ channel blocker and acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo.

Technical Data

M.Wt:
412.44
Formula:
C26H18F2N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
160588-45-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615. PMID: 9804701.

Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724. PMID: 9580619.

If you know of a relevant citation for this product please let us know.

Keywords: DMP 543, supplier, K+, channels, blockers, potent, ACh, release, enhancer, Potent, orally, active, Potassium, Channels, Non-Selective, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, DMP543

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

Sign-up for New Product E-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

BDS I

Potent and reversible Kv3.4 potassium channel blocker; neuroprotective

Agitoxin 2

Potent Shaker K+ channel blocker

MaxiPost

Potassium channel modulator; exerts subtype-specific effects

ML 277

Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.