Cat. No. 0911
Alternative Name: Glyburide
Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
Biological ActivityATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.
Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.
Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.
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Keywords: Glibenclamide, supplier, K+, channel, blockers, KATP, Blocks, CFTR, Cl-, channels, Potassium, KIR, Inward, Rectifier, Chloride, kir6
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