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Glibenclamide

Cat. No. 0911

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Alternative Name: Glyburide

Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

Biological Activity

ATP-dependent K⁺ channel (K_ir6, K_ATP) and CFTR Cl^- channel blocker. Inhibits K_ir6 currents in the pancreas, causing an increase in intracellular Ca²⁺ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC₅₀ of 20 μM.

Technical Data

M.Wt:

494

Formula:

C₂₃H₂₈CIN₃O₅S

Solubility:

Soluble to 100 mM in DMSO and to 5 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

10238-21-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.

Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.

Sheppard and Welsh (1992) Effect of ATP-sensitive K⁺ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.

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