Cat. No. 0911
Alternative Name: Glyburide
Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamin
Biological ActivityATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.
Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.
Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Glibenclamide, supplier, K+, channel, blockers, KATP, Blocks, CFTR, Cl-, channels, Potassium, KIR, Inward, Rectifier, Chloride, kir6
Find multiple products by catalog number
New Products in this Area
Potent TREK-1 channel inhibitorLei-Dab 7
Potent, selective KCa2.2 blockerNS 8593 hydrochloride
Selective KCa2 (SK) channel negative modulator; inhibits SK currentsPK-THPP
Potent TASK-3 channel blockerML 297
Selective Kir3.1/3.2 (GIRK1/2) channel activator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.