R&D Systems Inc. Tocris Bioscience Boston Biochem

Glibenclamide

Cat. No. 0911

Glibenclamide C23H28ClN3O5S [10238-21-8]

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Alternative Name: Glyburide

Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

Biological Activity

ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Technical Data

M.Wt:
494
Formula:
C23H28ClN3O5S
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
10238-21-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.

Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.

Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.

If you know of a relevant citation for this product please let us know.

Keywords: Glibenclamide, supplier, K+, channel, blockers, KATP, Blocks, CFTR, Cl-, channels, Potassium, KIR, Inward, Rectifier, Chloride, kir6

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