Cat. No. 0911
Alternative Name: Glyburide
Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamin
Biological ActivityATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Brogden et al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600.
Robertson et al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993.
Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Glibenclamide, supplier, K+, channel, blockers, KATP, Blocks, CFTR, Cl-, channels, Potassium, KIR, Inward, Rectifier, Chloride, kir6
Find multiple products by catalog number
New Products in this Area
Potent KCa3.1 blockerBDS I
Potent and reversible Kv3.4 potassium channel blocker; neuroprotectiveAgitoxin 2
Potent Shaker K+ channel blockerMaxiPost
Potassium channel modulator; exerts subtype-specific effectsML 277
Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current
August 30 - September 4, 2014
Booth Number: 22