Cat. No. 1222
Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Biological ActivityA potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627. PMID: 8064792.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: DMPQ dihydrochloride, supplier, Potent, selective, inhibitors, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs
Find multiple products by catalog number
New Products in this Area
Multi-RTK inhibitor; inhibits angiogenesisGNF 5837
Potent Trk inhibitor; inhibits TrkA, TrkB and TrkCHKI 357
Dual irreversible inhibitor of ErbB2 and EGFR
Win a Kindle
December 17 - 19, 2013