R&D Systems Inc. Tocris Bioscience Boston Biochem

DMPQ dihydrochloride

Cat. No. 1222

DMPQ dihydrochloride C16H14N2O2.2HCl [1123491-15-5]

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Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

Biological Activity

A potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

Technical Data

M.Wt:
339.22
Formula:
C16H14N2O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
1123491-15-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627. PMID: 8064792.

If you know of a relevant citation for this product please let us know.

Keywords: DMPQ dihydrochloride, supplier, Potent, selective, inhibitors, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs

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