R&D Systems Inc. Tocris Bioscience Boston Biochem

DMPQ dihydrochloride

Cat. No. 1222

DMPQ dihydrochloride C16H14N2O2.2HCl [1123491-15-5]

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Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

Biological Activity

A potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

Technical Data

M.Wt:
339.22
Formula:
C16H14N2O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
1123491-15-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627. PMID: 8064792.

If you know of a relevant citation for this product please let us know.

Keywords: DMPQ dihydrochloride, supplier, Potent, selective, inhibitors, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs

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