Cat. No. 1222
Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinol
Biological ActivityA potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627. PMID: 8064792.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: DMPQ dihydrochloride, supplier, Potent, selective, inhibitors, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs
Find multiple products by catalog number
New Products in this Area
Highly potent HGF/c-MET inhibitor; also AT4 antagonistAEE 788
Potent EGFR and VEGFR inhibitorXL 184
Potent VEGFR inhibitor; also inhibits other RTKsPKI 166 hydrochloride
Potent EGFR-kinase inhibitorASP 3026
Potent anaplastic lymphoma kinase (ALK) inhibitorKYL
EphA4 receptor tyrosine kinase inhibitor; neuroprotectivePD 90780
Inhibits NGF binding to p75NTRLM11A 31 dihydrochloride
Nonpeptide p75NTR ligand; neuroprotectiveEG 00229
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
April 18 - 22, 2015