Cat. No. 0686
Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy
Biological ActivityLong-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129. PMID: 2626444.
Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113. PMID: 8604434.
Capsoni et al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432. PMID: 12205295.
Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024. PMID: 12649296.
Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103. PMID: 14654102.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Galanthamine hydrobromide, supplier, Galanthamine, Galantamine, Cholinesterase, inhibitors, AChE, Acetylcholinesterase, Esterases, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR