R&D Systems Inc. Tocris Bioscience Boston Biochem

Galanthamine hydrobromide

Cat. No. 0686

Galanthamine hydrobromide C17H21NO3.HBr [1953-04-4]

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Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

Biological Activity

Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Technical Data

M.Wt:
368.27
Formula:
C17H21NO3.HBr
Solubility:
Soluble to 50 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
1953-04-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129. PMID: 2626444.

Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113. PMID: 8604434.

Capsoni et al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432. PMID: 12205295.

Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024. PMID: 12649296.

Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103. PMID: 14654102.

If you know of a relevant citation for this product please let us know.

Keywords: Galanthamine hydrobromide, supplier, Galanthamine, Galantamine, Cholinesterase, inhibitors, AChE, Acetylcholinesterase, Esterases, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR

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