R&D Systems Inc. Tocris Bioscience Boston Biochem

Galanthamine hydrobromide

Cat. No. 0686

Galanthamine hydrobromide C17H21NO3.HBr [1953-04-4]

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Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

Biological Activity

Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Technical Data

Soluble to 50 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129. PMID: 2626444.

Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113. PMID: 8604434.

Capsoni et al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432. PMID: 12205295.

Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024. PMID: 12649296.

Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103. PMID: 14654102.

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Keywords: Galanthamine hydrobromide, supplier, Galanthamine, Galantamine, Cholinesterase, inhibitors, AChE, Acetylcholinesterase, Esterases, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR

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