Cat. No. 0524
Chemical Name: 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
Biological ActivitySelective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Ismaiel et al (1993) Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist. J.Med.Chem. 36 2519. PMID: 8355253.
Czoty et al (2000) Behavioural effects of AMI-193, a 5-HT2A- and dopamine D2-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67 257. PMID: 11124389.
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Keywords: AMI-193, supplier, Selective, 5-HT2, antagonists, D2-like, receptor, Non-Selective, Serotonin, Receptors, Dopamine, dopaminergic
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