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L-152,804

Cat. No. 1382

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Chemical Name: 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione

Biological Activity

Potent, selective non-peptide neuropeptide Y Y₅ receptor antagonist (K_i = 26 nM for hY₅). Displays > 300-fold selectivity over hY₁, hY₂, and hY₄ receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.

Technical Data

M.Wt:

366.46

Formula:

C₂₃H₂₆O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

6508-43-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kanatani et al (2000) L-152,804: orally active and selective neuropeptide Y Y₅ receptor antagonist. Biochem.Biophys.Res.Commun. 272 169. PMID: 10872822.

Schroeder et al (2005) The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol 36 179. PMID: 16377459.

Mashiko et al (2007) A pair-feeding study reveals that a Y₅ antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol.Pharmacol. 71 602. PMID: 17105869.

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Keywords: L-152,804, supplier, Potent, selective, non-peptide, NPY, Y5, antagonists, Neuropeptide, Y, Receptors, L152804, neuropeptides

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