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Sphingosine-1-phosphate

Cat. No. 1370

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Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol

Biological Activity

Endogenous second messenger involved in the control of cell proliferation and motility, and Ca²⁺ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P_1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Technical Data

M.Wt:

379.48

C₁₈H₃₈NO₅P

>98 %

Desiccate at +4°C

26993-30-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

van Koppen et al (1996) Activation of a high affinity G_i protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J.Biol.Chem. 271 2082. PMID: 8567663.

Pyne and Pyne (2000) Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacol.Ther. 88 115. PMID: 11150592.

Essler et al (2002) Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. Cell.Signal. 14 607. PMID: 11955953.

Uhlenbrock et al (2002) Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell.Signal. 14 941. PMID: 12220620.

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7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy