Cat. No. 1370
Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogen
Biological ActivityEndogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
van Koppen et al (1996) Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J.Biol.Chem. 271 2082. PMID: 8567663.
Pyne and Pyne (2000) Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacol.Ther. 88 115. PMID: 11150592.
Essler et al (2002) Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. Cell.Signal. 14 607. PMID: 11955953.
Uhlenbrock et al (2002) Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell.Signal. 14 941. PMID: 12220620.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Sphingosine-1-phosphate, supplier, Endogenous, agonists, S1P1, S1P2, S1P3, S1P4, S1P5, Receptors, EDG, Sphingosine-1-Phosphate, GPR3, GPR6, GPR12
Find multiple products by catalog number
New Products in this Area
Potent and selective FFA4 (GPR120) agonistAH 7614
Selective FFA4 (GPR120) antagonistProsaptide TX14(A)
Potent GPR37 and GPR37L1 agonistAS 2034178
Selective FFA1 (GPR40) agonist(±)-NBI 74330
Potent and selective CXCR3 antagonistPurmorphamine
Smo receptor agonistCTCE 9908
CXCR4 antagonist; antitumorVUF 11207 fumarate
Potent CXCR7 agonistTC-G 1006
Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
August 30 - September 4, 2014
Booth Number: 22