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Prostaglandin E₂

Cat. No. 2296

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Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid

Biological Activity

Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP₁, EP₂, EP₃ and EP₄ receptors (K_d values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.

Technical Data

M.Wt:

352.47

Formula:

C₂₀H₃₂O₅

Solubility:

Soluble to 100 mM in DMSO and to 45 mM in ethanol

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

363-24-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Coleman et al (1994) Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 46 205. PMID: 7938166.

Hata and Breyer (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther. 103 147.

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007. PMID: 17581586.

If you know of a relevant citation for this product please let us know.

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Keywords: Prostaglandin E2, supplier, endogenous, prostanoid, EP1, EP2, EP3, EP4, Receptors, prostaglandins, prostacyclins, eicosanoids, ProstaglandinE2, stem, cells, e2

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