R&D Systems Inc. Tocris Bioscience Boston Biochem

Cordycepin

Cat. No. 2294

Cordycepin C10H13N5O3 [73-03-0]

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Chemical Name: 3'-Deoxyadenosine

Biological Activity

Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Technical Data

M.Wt:
251.24
Formula:
C10H13N5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
73-03-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804. PMID: 779831.

Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424. PMID: 9624488.

Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 59 273. PMID: 10609556.

If you know of a relevant citation for this product please let us know.

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Keywords: Cordycepin, supplier, RNA, synthesis, inhibitors, Protein, DNA

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