R&D Systems Inc. Tocris Bioscience Boston Biochem

Cordycepin

Cat. No. 2294

Cordycepin C10H13N5O3 [73-03-0]

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Chemical Name: 3'-Deoxyadenosine

Biological Activity

Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Technical Data

M.Wt:
251.24
Formula:
C10H13N5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
73-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804. PMID: 779831.

Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424. PMID: 9624488.

Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 59 273. PMID: 10609556.

If you know of a relevant citation for this product please let us know.

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Keywords: Cordycepin, supplier, RNA, synthesis, inhibitors, Protein, DNA

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