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Cordycepin

Cat. No. 2294

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Chemical Name: 3'-Deoxyadenosine

Biological Activity

Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Technical Data

M.Wt:

251.24

Formula:

C₁₀H₁₃N₅O₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

73-03-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804. PMID: 779831.

Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424. PMID: 9624488.

Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT⁺) leukemic cells. Biochem.Pharmacol. 59 273. PMID: 10609556.

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