Sibutramine hydrochloride

Cat No. 2290

Sibutramine hydrochloride C17H26NCl.HCl [84485-00-7]

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Alternative Name: BTS 54-524

Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclo butanemethanamine hydrochloride

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M.Wt:
316.31
Formula:
C17H26NCl.HCl
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
[84485-00-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
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Material Safety Data Sheet: View current batch
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References

Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575. Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758. Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581.

If you know of a useful citation for this product please let us know.

View Related Products by Target

5-HT TransportersAdrenergic Transporters
Neurotransmitter Transporters

Keywords: Sibutramine hydrochloride, 5-HT, noradrenalin, reuptake, inhibitors, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, BTS54524

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