Go 6983

Cat. No. 2285

Go 6983 C26H26N4O3 [133053-19-7]

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Alternative Name: Goe 6983

Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Biological Activity

Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

Technical Data

M.Wt:
442.51
Formula:
C26H26N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
133053-19-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Gschwendt et al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77. PMID: 8772178.

Peterman et al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645. PMID: 15071351.

Young et al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255. PMID: 16252018.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Go 6983, supplier, Broad, spectrum, PKC, inhibitors, Protein, Kinases, C, Go6983, Goe6983

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