Cat. No. 2285
Alternative Name: Goe 6983
Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-me
Biological ActivityBroad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Gschwendt et al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77. PMID: 8772178.
Peterman et al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645. PMID: 15071351.
Young et al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255. PMID: 16252018.
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Keywords: Go 6983, supplier, Broad, spectrum, PKC, inhibitors, Protein, Kinases, C, Go6983, Goe6983
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