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Moxonidine hydrochlorideCat. No. 2282 |
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Chemical Name: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine hydrochloride |
Biological Activity
Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Centrally acting antihypertensive agent.Certificate of Analysis / Safety Data Sheet
References
Schafer et al (2002) Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and α2-adrenoceptors. J.Pharmacol.Exp.Ther. 303 1163. PMID: 12438540.
El-Ayoubi et al (2004) Imidazoline receptors but not a2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J.Pharmacol.Exp.Ther. 310 446. PMID: 15075383.
Chan et al (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience 132 991. PMID: 15857704.
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Keywords: Moxonidine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, I1, receptors, Imidazoline
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