(±)-Epibatidine

Cat. No. 0684

()-Epibatidine C11H13ClN2 [148152-66-3]

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Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane

Biological Activity

High affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Licensing Information

Sold under license from the NIH, US Patent 5,314,899

Technical Data

M.Wt:
208.69
Formula:
C11H13ClN2
Solubility:
Soluble to 5 mM in water and to 100 mM in ethanol
Storage:
Desiccate at +4°C
CAS No:
148152-66-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475.

Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563. PMID: 8183234.

Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774. PMID: 7476906.

Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377. PMID: 9536034.

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783. PMID: 10751429.

If you know of a relevant citation for this product please let us know.

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Keywords: ()-Epibatidine, supplier, potent, nicotinic, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonists

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