R&D Systems Inc. Tocris Bioscience Boston Biochem

MRS 1220

Cat. No. 1217

MRS 1220 C21H14ClN5O2 [183721-15-5]

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Chemical Name: N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide

Biological Activity

A potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value > 1 μM for inhibition of binding to rat A3 receptors).

Licensing Information

Sold with the permission of the NIH, US Patent 60/029,855

Technical Data

M.Wt:
403.83
Formula:
C21H14ClN5O2
Solubility:
Soluble to 100 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
183721-15-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Kim et al (1996) Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) are selective for the human A3 receptor subtype. J.Med.Chem. 39 4142. PMID: 8863790.

Jacobson et al (1997) Pharmacological characterization of novel A3 adenosine receptor selective antagonists. Neuropharmacology 36 1157. PMID: 9364471.

Kim et al (1998) Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. J.Med.Chem. 41 2835. PMID: 9667972.

If you know of a relevant citation for this product please let us know.

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Keywords: MRS 1220, supplier, potent, selective, hA3, antagonists, Receptors, adenosines, MRS1220

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