MRS 1220

Cat. No. 1217

MRS 1220 C21H14ClN5O2 [183721-15-5]

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Chemical Name: N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide

Biological Activity

A potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value > 1 μM for inhibition of binding to rat A3 receptors).

Licensing Information

Sold with the permission of the NIH, US Patent 60/029,855

Technical Data

Soluble to 100 mM in DMSO with gentle warming
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Kim et al (1996) Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) are selective for the human A3 receptor subtype. J.Med.Chem. 39 4142. PMID: 8863790.

Jacobson et al (1997) Pharmacological characterization of novel A3 adenosine receptor selective antagonists. Neuropharmacology 36 1157. PMID: 9364471.

Kim et al (1998) Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. J.Med.Chem. 41 2835. PMID: 9667972.

If you know of a relevant citation for this product please let us know.

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Keywords: MRS 1220, supplier, potent, selective, hA3, antagonists, Receptors, adenosines, MRS1220, A3 Receptor Antagonists

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