PD 98059

Cat. No. 1213

PD 98059 C16H13NO3 [167869-21-8]

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Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Biological Activity

Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™.

Technical Data

M.Wt:
267.28
Formula:
C16H13NO3
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
167869-21-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Alessi et al (1995) PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J.Biol.Chem. 270 27489. PMID: 7499206.

Dudley et al (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc.Natl.Acad.Sci.U.S.A. 92 7686. PMID: 7644477.

Tsang et al (1998) Effects of mitogen-activated protein kinase kinase inhibitor PD 98059 on antigen challenge of guinea-pig airways in vitro. Br.J.Pharmacol. 125 61. PMID: 9776345.

Qi et al (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc.Natl.Acad.Sci.USA 101 6027. PMID: 15075392.

Kojima et al (2007) Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells. 67 3210. PMID: 17409429.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PD 98059, supplier, Specific, inhibitors, MEK, MKK, Mitogen-Activated, Protein, Kinase, Kinases, PD98059, stem, cells

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