Doxepin hydrochlorideCat No. 0508 |
Price and Availability |
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Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e] oxepin hydrochloride |
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Biological Activity
Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Merck Index 12 3492. Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501. Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006. Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427.If you know of a useful citation for this product please let us know.
Keywords: Doxepin hydrochloride, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic
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