Cat. No. 1368
Chemical Name: 9,13-Dihydroxy-8,14,19-trimethoxy-4
Biological ActivitySelectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates anti-proliferative effects on breast cancer cells in a dose dependent manner.
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Certificate of Analysis / Safety Data Sheet
Whitesell et al (1994) Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc.Natl.Acad.Sci.U.S.A. 91 8324. PMID: 8078881.
Cardenas et al (1998) Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol. 16 427. PMID: 9807840.
Roe et al (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanomycin. J.Med.Chem. 42 260. PMID: 9925731.
Lee et al (2012) Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie. 94 1382. PMID: 22445681.
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Keywords: Geldanamycin, supplier, Selective, Hsp90, inhibitors, Heat, Shock, Protein, 90, antibiotics