R&D Systems Inc. Tocris Bioscience Boston Biochem

Geldanamycin

Cat. No. 1368

Geldanamycin C29H40N2O9 [30562-34-6]

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Chemical Name: 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate

Biological Activity

Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates anti-proliferative effects on breast cancer cells in a dose dependent manner.

Technical Data

M.Wt:
560.64
Formula:
C29H40N2O9
Solubility:
Soluble in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
30562-34-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Whitesell et al (1994) Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc.Natl.Acad.Sci.U.S.A. 91 8324. PMID: 8078881.

Cardenas et al (1998) Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol. 16 427. PMID: 9807840.

Roe et al (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanomycin. J.Med.Chem. 42 260. PMID: 9925731.

Lee et al (2012) Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie. 94 1382. PMID: 22445681.

If you know of a relevant citation for this product please let us know.

Keywords: Geldanamycin, supplier, Selective, Hsp90, inhibitors, Heat, Shock, Protein, 90, antibiotics

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