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Domoic acidCat. No. 0269 |
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Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid |
Biological Activity
More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.Certificate of Analysis / Safety Data Sheet
References
Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345. PMID: 3513882.
Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29. PMID: 2540893.
Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed 49.
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Keywords: Domoic acid, supplier, Potent, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic
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