R&D Systems Inc. Tocris Bioscience Boston Biochem

Domoic acid

Cat. No. 0269

Domoic acid C15H21NO6 [14277-97-5]

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Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid

Biological Activity

Kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Technical Data

M.Wt:
311.33
Formula:
C15H21NO6
Solubility:
Soluble to 50 mM in water
Purity:
>95 %
Storage:
Desiccate at -20°C
CAS No:
14277-97-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345. PMID: 3513882.

Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29. PMID: 2540893.

Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed 49.

Hampson and Manalo (1998) The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 6 153. PMID: 10223631.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Domoic acid, supplier, Potent, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic

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