Domoic acid

Cat. No. 0269

Domoic acid C15H21NO6 [14277-97-5]

Price and Availability

For Domoic acid pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid

Biological Activity

Kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Technical Data

Soluble to 50 mM in water
>95 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet


Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345. PMID: 3513882.

Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29. PMID: 2540893.

Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed 49.

Hampson and Manalo (1998) The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 6 153. PMID: 10223631.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Domoic acid, supplier, Potent, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Kainate Receptor Agonists

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

An overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

A summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Updated in 2014 - this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis. Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

New Products in this Area


Potent and noncompetitive NMDA receptor antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.