MRS 2179 tetrasodium salt
Cat. No. 0900
Chemical Name: 2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt
Biological ActivityA competitive antagonist at P2Y1 receptors (KB = 100 nM). Selective over P2X1 (IC50 = 1.15 μM), P2X3 (IC50 = 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. Inhibits the upregulation of NTPDase1 by ATPγS.
Licensing InformationSold under license from the NIH, US Patent 60/029,855
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Boyer et al (1998) Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br.J.Pharmacol. 124 1. PMID: 9630335.
Brown et al (2000) Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev.Res. 49 253.
Nandanan et al (2000) Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. J.Med.Chem. 43 829. PMID: 10715151.
Lu et al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157. PMID: 17626796.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: MRS 2179 tetrasodium salt, supplier, Selective, P2Y1, antagonists, Receptors, Purinergic, purinoceptors, MRS2179, tetrasodium, salt
Find multiple products by catalog number
New Products in this Area
P2Y12 inhibitorRactopamine hydrochloride
Trace amine 1 (TA1) receptor agonistTG 4-155
High affinity and selective EP2 receptor antagonistSAG
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathwayDC 260126
FFA1 (GPR40) antagonistAR-C 118925XX
Selective, competitive P2Y2 receptor antagonistEPPTB
Trace amine 1 (TA1) receptor antagonist/inverse agonistNIBR 189
Potent and selective EBI2 (GPR183) receptor antagonistONO AE3 208
High affinity and selective EP4 antagonist
April 12 - 15, 2015