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MRS 2179 tetrasodium salt

Cat. No. 0900

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Chemical Name: 2'-Deoxy-N⁶-methyladenosine 3',5'-bisphosphate tetrasodium salt

Biological Activity

A competitive antagonist at P2Y₁ receptors (K_B = 100 nM). Selective over P2X₁ (IC₅₀ = 1.15 μM), P2X₃ (IC₅₀ = 12.9 μM), P2X₂, P2X₄, P2Y₂, P2Y₄ and P2Y₆ receptors. Inhibits the upregulation of NTPDase1 by ATPγS.

Licensing Information

Sold under license from the NIH, US Patent 60/029,855

Technical Data

M.Wt:

513.16

Formula:

C₁₁H₁₃N₅O₉P₂Na₄

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

101204-49-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Boyer et al (1998) Competitive and selective antagonism of P2Y₁ receptors by N⁶-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br.J.Pharmacol. 124 1. PMID: 9630335.

Brown et al (2000) Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev.Res. 49 253.

Nandanan et al (2000) Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y₁ receptor ligands. J.Med.Chem. 43 829. PMID: 10715151.

Lu et al (2007) Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157. PMID: 17626796.

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