TBB

Cat. No. 2275

TBB C6HBr4N3 [17374-26-4]

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Alternative Name: NSC 231634

Chemical Name: 4,5,6,7-Tetrabromobenzotriazole

Biological Activity

A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Technical Data

M.Wt:
434.71
Formula:
C6HBr4N3
Solubility:
Soluble to 100 mM in DMSO and to 15 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
17374-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sarno et al (2001) Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett. 496 44. PMID: 11343704.

Pagano et al (2004) Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J.Med.Chem. 47 6239. PMID: 15566294.

Zien et al (2005) Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim.Biophys.Acta. 1754 271. PMID: 16203192.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TBB, supplier, Selective, cell-permeable, CK2, inhibitors, Casein, Kinase, 2, Kinases, NSC231634

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