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TBB

Cat. No. 2275

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Alternative Name: NSC 231634

Chemical Name: 4,5,6,7-Tetrabromobenzotriazole

Biological Activity

A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC₅₀ = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K_i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Technical Data

M.Wt:

434.71

Formula:

C₆HBr₄N₃

Solubility:

Soluble to 100 mM in DMSO and to 15 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

17374-26-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sarno et al (2001) Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett. 496 44. PMID: 11343704.

Pagano et al (2004) Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J.Med.Chem. 47 6239. PMID: 15566294.

Zien et al (2005) Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim.Biophys.Acta. 1754 271. PMID: 16203192.

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