R&D Systems Inc. Tocris Bioscience Boston Biochem

Ro 08-2750

Cat. No. 2272

Ro 08-2750 C13H10N4O3 [37854-59-4]

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Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde

Biological Activity

Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Inhibits binding selectively to p75NTR at submicromolar concentrations and to both p75NTR and TrkA at higher concentrations (> 5 μM). Prevents NGF-induced apoptosis in SK-N-MC cells.

Technical Data

M.Wt:
270.24
Formula:
C13H10N4O3
Solubility:
Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO with gentle warming
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
37854-59-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Niederhauser et al (2000) NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 61 263. PMID: 10900073.

Arkin and Wells (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 3 301. PMID: 15060526.

If you know of a relevant citation for this product please let us know.

Keywords: Ro 08-2750, supplier, inhibitors, NGF, binding, p75NTR, TrkA, Neurotrophin, Receptors, p75, Trk, Receptor, Tyrosine, Kinases, RTKs, Ro08-2750

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