R&D Systems Inc. Tocris Bioscience Boston Biochem

Ro 08-2750

Cat. No. 2272

Ro 08-2750 C13H10N4O3 [37854-59-4]

Price and Availability

For Ro 08-2750 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde

Biological Activity

Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells.

Technical Data

M.Wt:
270.24
Formula:
C13H10N4O3
Solubility:
Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO with gentle warming
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
37854-59-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Niederhauser et al (2000) NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 61 263. PMID: 10900073.

Arkin and Wells (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 3 301. PMID: 15060526.

If you know of a relevant citation for this product please let us know.

Keywords: Ro 08-2750, supplier, inhibitors, NGF, binding, p75NTR, TrkA, Neurotrophin, Receptors, p75, Trk, Receptor, Tyrosine, Kinases, RTKs, Ro08-2750

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Poster

A summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request a copy or view PDF today.

divider line

Parkinson's Disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Poster

'Updated in 2014 - this poster summarizes the neurobiology of Parkinson's Disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

ASP 3026

Potent anaplastic lymphoma kinase (ALK) inhibitor

KYL

EphA4 receptor tyrosine kinase antagonist; neuroprotective

PD 90780

Inhibits NGF binding to p75NTR

LM11A 31 dihydrochloride

Nonpeptide p75NTR ligand; neuroprotective

EG 00229

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Toceranib

Potent PDGFR and VEGFR inhibitor

NVP ADW 742

ATP-competitive inhibitor of IGF1R

KRCA 0008

Potent Ack1 and ALK dual inhibitor; orally bioavailable

DDR1-IN-1 dihydrochloride

Selective DDR1 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.