R&D Systems Inc. Tocris Bioscience Boston Biochem

WRW4

Cat. No. 2262

WRW4 Trp-Arg-Trp-Trp-Trp-Trp-NH2

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Alternative Name: WRW4

Biological Activity

Selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data

M.Wt:
1104.28
Formula:
C61H65N15O6
Sequence:
WRWWWW

(Modifications: Trp-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 25% ethanol / water
Storage:
Desiccate at -20°C
CAS No:
878557-55-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607. PMID: 15210823.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: WRW4, supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors

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