Cat. No. 2262
Alternative Name: WRW4
Biological ActivitySelective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
(Modifications: Trp-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607. PMID: 15210823.
If you know of a relevant citation for this product please let us know.
Keywords: WRW4, supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors
Find multiple products by catalog number
New Products in this Area
Selective PAR4 antagonistGW 438014A
NPY Y5 receptor antagonistTC-FPR 43
Potent FPR2 agonistTC-G 1003
High affinity somatostatin sst2 receptor agonistKisspeptin 10 (dog)
Endogenous ligand for canine kisspeptin receptorMK 0677
High affinity ghrelin receptor agonistUrantide
Selective and competitive urotensin II receptor antagonist
April 18 - 22, 2015