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ACDPP hydrochlorideCat. No. 2254 |
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Chemical Name: 3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride |
Biological Activity
Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.Certificate of Analysis / Safety Data Sheet
References
Bonnefous et al (2005) Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 15 1197. PMID: 15686941.
Wang et al (2008) Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 28 4385. PMID: 18434517.
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Keywords: ACDPP hydrochloride, supplier, Selective, mGlu5, mGluR5, receptor, antagonists, mGlur, Group, I, Receptors, Glutamate, Metabotropic
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