SL 0101-1

Cat. No. 2250

SL 0101-1 C25H24O12 [77307-50-7]

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Chemical Name: 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one

Biological Activity

Selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.  Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

Technical Data

M.Wt:
516.46
Formula:
C25H24O12
Solubility:
Soluble to 20 mM in ethanol and to 10 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
77307-50-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Smith et al (2005) Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 65 1027. PMID: 15705904.

Godeny and Sayeski (2006) ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am.J.Cell.Physiol. 291 1308.

Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297. PMID: 17850214.

If you know of a relevant citation for this product please let us know.

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RSK

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Keywords: SL 0101-1, supplier, Selective, p90, ribosomal, S6, kinases, RSK, inhibitors, SL0101-1, Tocris Bioscience, RSK Inhibitors

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