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Dimaprit dihydrochlorideCat. No. 0506 |
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Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride |
Biological Activity
Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).Certificate of Analysis / Safety Data Sheet
References
Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39. PMID: 860674.
Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31. PMID: 871093.
Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331. PMID: 10385230.
Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169. PMID: 10980276.
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Keywords: Dimaprit dihydrochloride, supplier, H2, selective, agonists, Receptors, Histamine, histaminergic
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