Dimaprit dihydrochloride

Cat. No. 0506

Dimaprit dihydrochloride C6H15N3S.2HCl [23256-33-9]

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Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride

Biological Activity

Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).

Technical Data

Soluble to 100 mM in water
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39. PMID: 860674.

Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31. PMID: 871093.

Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331. PMID: 10385230.

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169. PMID: 10980276.

If you know of a relevant citation for this product please let us know.

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Keywords: Dimaprit dihydrochloride, supplier, H2, selective, agonists, Receptors, Histamine, histaminergic, Histamine H2 Receptor Agonists

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