R&D Systems Inc. Tocris Bioscience Boston Biochem

Dimaprit dihydrochloride

Cat. No. 0506

Dimaprit dihydrochloride C6H15N3S.2HCl [23256-33-9]

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Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride

Biological Activity

Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).

Technical Data

M.Wt:
234.19
Formula:
C6H15N3S.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
23256-33-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39. PMID: 860674.

Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31. PMID: 871093.

Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331. PMID: 10385230.

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169. PMID: 10980276.

If you know of a relevant citation for this product please let us know.

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Keywords: Dimaprit dihydrochloride, supplier, H2, selective, agonists, Receptors, Histamine, histaminergic

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