Cat. No. 0506
Chemical Name: S-(3-Dimethylaminopropyl)isothioure
Biological ActivitySelective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39. PMID: 860674.
Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31. PMID: 871093.
Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331. PMID: 10385230.
Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169. PMID: 10980276.
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Keywords: Dimaprit dihydrochloride, supplier, H2, selective, agonists, Receptors, Histamine, histaminergic
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June 24 - 27, 2015
Booth Number: B11:25