Cat. No. 1125
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihy
Biological ActivityAntitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPR30) receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 8216.
Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583. PMID: 6311542.
Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227. PMID: 6091650.
Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952. PMID: 8069862.
Cermak et al (2002) The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183. PMID: 11877325.
Saponara et al (2002) Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819. PMID: 11934824.
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Keywords: Quercetin, supplier, Non-Selective, PI, 3-kinase, inhibitors, GPR30, agonists, non-selective, 3-Kinase, PI3K, Akt, Signaling, Signalling, PIP2, Inositol, Lipids, cAMP, Receptors, Estrogen, receptors, Phosphoinositide, Kinases, GPER
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