Cat. No. 1007
Alternative Names: Normethylclozapine, Norclozapine
Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Biological ActivityA major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT1C receptor antagonists. Eur.J.Pharmacol. 245 179. PMID: 8387927.
Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharmacol. 301 27. PMID: 8773443.
Wong et al (1996) Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors. Eur.J.Pharmacol. 314 319. PMID: 8957253.
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Keywords: N-Desmethylclozapine, supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine
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