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N-Desmethylclozapine

Cat. No. 1007

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Alternative Names: Normethylclozapine, Norclozapine

Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT_2C serotonin receptor antagonist.

Technical Data

M.Wt:

312.8

Formula:

C₁₇H₁₇ClN₄

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

6104-71-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Kuoppam�ki et al (1993) Clozapine and methylclozapine are potent 5-HT_1C receptor antagonists. Eur.J.Pharmacol. 245 179. PMID: 8387927.

Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharmacol. 301 27. PMID: 8773443.

Wong et al (1996) Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABA_A receptors. Eur.J.Pharmacol. 314 319. PMID: 8957253.

If you know of a relevant citation for this product please let us know.

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Keywords: N-Desmethylclozapine, supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine

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